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Vardenafil Vs Sildenafil: Which One to Buy?

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    Vardenafil and Sildenafil are renowned medications for treating Erectile Dysfunction (ED) in men or Assigned Males at Birth (AMAB). Understanding the differences and similarities between these two drugs is crucial for making an informed decision. This article aims to explore the most asked questions about Vardenafil and Sildenafil, providing a comprehensive guide on which medication might be the best choice for individual needs.

    Sildenafil and Vardenafil Basics


    • Approval: First FDA-approved medication for ED in 1998.
    • Brand Names: Viagra, Generic Viagra.
    • Other Uses: Treats Pulmonary Arterial Hypertension.


    • Approval: FDA approved in 2003.
    • Brand Names: Levitra, Vilitra, Filitra, Snovitra.
    • Primary Use: Exclusively for treating Erectile Dysfunction.

    Vardenafil vs Sildenafil: How Do They Work?

    Both Vardenafil and Sildenafil belong to the group of Phosphodiesterase type 5 (PDE5) inhibitors, which function by inhibiting PDE5 and increasing levels of cyclic Guanosine Monophosphate (cGMP). This action relaxes smooth muscles and dilates blood vessels in the penile region, facilitating increased blood circulation and aiding in achieving a strong erection when sexually stimulated.

    Whose Effects Last Longer: Vardenafil or Sildenafil?

    The duration of effect varies slightly between the two:

    • Vardenafil: Typical half-life of 4-6 hours, with effects lasting up to 8 hours in some cases.
    • Sildenafil: Half-life of 3 to 5 hours, with effects starting to wear off within 3 hours.

    Which Pill Works Faster: Vardenafil vs Sildenafil?

    Both medications generally start to work within 30 minutes of consumption. However, this can be influenced by individual health factors and dietary habits, particularly the consumption of high-fat meals which can delay absorption.

    Which Has More Side Effects: Vardenafil or Sildenafil?

    Common side effects for both medications include headache, dizziness, nausea, flushing, heartburn, upset stomach, back pain, sleep problems, stuffy or runny nose, vision changes, lightheadedness, irregular heartbeat, shortness of breath, and priapism.

    Sildenafil vs Vardenafil: A Comparison

    GroupPDE5 inhibitorsPDE5 inhibitors
    Treatment ofErectile DysfunctionErectile Dysfunction, Pulmonary Arterial Hypertension
    Brand Name MedicineLevitraViagra
    Generics AvailableYesYes

    set of Action | 30 minutes | 30 minutes | | Effect Duration | 4 to 8 hours | 3 to 5 hours |

    Which is More Effective, Sildenafil or Vardenafil?

    Both Vardenafil and Sildenafil have shown high efficacy in treating Erectile Dysfunction. Studies indicate that:

    • Vardenafil: Showed improvement in erections for 92% of participants.
    • Sildenafil: Resulted in improved erections for 95% of participants.

    Which is Better, Vardenafil vs Sildenafil?

    Choosing between Vardenafil and Sildenafil depends on individual preferences and medical advice. Key points to consider:

    • Vardenafil: Has a slightly longer duration of effect.
    • Sildenafil: Widely used and also treats Pulmonary Arterial Hypertension.
    • Both: Have similar onset times and side effect profiles.

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    • Vardenafil: Offers long-lasting intimacy options.
    • Sildenafil: Provides a reliable and tested solution for ED.

    Frequently Asked Questions

    Does Vardenafil last longer than Sildenafil?

    Yes, typically, Vardenafil’s effects last between 4 to 6 hours, whereas Sildenafil’s effects last for about 3 to 5 hours.

    How long does it take for Vardenafil to work?

    It takes at least 30 minutes for Vardenafil to show effects, but this can vary based on health and dietary factors.

    How long does it take for Sildenafil to work?

    Sildenafil generally starts working within 30 minutes, though this can be delayed up to an hour depending on factors like high-fat meal consumption and individual health.